Biochem/physiol Actions

Reversible: yes

Product does not compete with ATP.

Primary TargetPKC

Target IC₅₀: 5 µM against protein kinase C

Cell permeable: yes

General description

Epidermal growth-factor receptor (EGF-R) conserved sequence which is identical to v-ErbB (95-102). An N-terminal myristoylated membrane-permeable, reversible, and substrate competitive inhibitor of protein kinase C (IC₅₀ = 5 µM).

Epidermal growth-factor receptor (EGF-R) conserved sequence which is identical to v-erbB (95-102). An N-terminal myristoylated membrane-permeable, reversible, and substrate competitive inhibitor that inhibits protein kinase C (IC₅₀ = 5 µM) in intact cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Ward, N.E., and O'Brian, C.A. 1993. Biochemistry32, 11903.O'Brian, C.A., et al. 1991. Invest. New Drugs 9, 169.

Packaging

Yes

500 µg in Plastic ampoule

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Sequence

Myr-N-Arg-Lys-Arg-Thr-Leu-Arg-Arg-Leu-OH

Warning

Toxicity: Standard Handling (A)